Kidney Friends

Individuals with a high resting heart rate
and a low beat-to-beat heart rate variability
have an increased risk of developing kidney disease..

Quote:Findings suggest that the behavior of the autonomic nervous system may be a sentinel marker for late development
of certain cases of kidney disease.

The autonomic nervous system regulates unconscious body functions, including heart rate, blood pressure, temperature regulation, and responses to stress. Dysfunction of the autonomic nervous system (dysautonomia) has been linked to chronic kidney disease (CKD) and its progression, but the details of this association are unclear.

To study the relationship between dysautonomia and the subsequent development of kidney disease, Daniel Brotman, MD (Johns Hopkins University School of Medicine) and his colleagues examined data from 13,241 individuals enrolled in the Atherosclerosis Risk in Communities (ARIC) study, a prospective observational cohort of 15,792 individuals aged 45 to 64 years, drawn from four US communities. To assess dysautonomia, the investigators measured heart rate variability, a practical way to measure autonomic balance.

In most healthy young adults, resting heart rate will predictably accelerate and decelerate as a person breathes. In general, lower resting heart rates and greater beat-to-beat variability in heart
rate indicate a healthy autonomic nervous system and good cardiovascular health. On the other hand, higher resting heart
rates and lower beat-to-beat variability in heart rate are signs of dysautonomia.

Dr. Brotman and his team found that patients with higher resting heart rates had a 2-fold increased risk of developing kidney failure many years later. Individuals with a lower beat-to-beat variability in heart rate had a 1.5-fold increased risk. Therefore, heart rate measurements could serve as a way to identify patients at higher risk of developing kidney damage.

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